NIPRO®

Brizio™ Oxygenator

Name: Brizio™ Oxygenator
Brand: Nipro

Membrane oxygenator and venous reservoir with integrated cardiotomy filter — Adult

BRIZIO™ is an adult cardiopulmonary bypass solution that combines a venous reservoir with an integrated cardiotomy filter and an E8 synthetic-coated membrane oxygenator in a single system. It is designed for low priming volume, effective microbubble removal and high gas-transfer performance.

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INDICATIONS & USE

An integrated solution for adult cardiopulmonary bypass

BRIZIO™ is designed for oxygenating blood, removing carbon dioxide and controlling blood temperature in adult cardiopulmonary bypass (CPB) circuits, and for collecting, filtering and storing venous and cardiotomy blood.

Blood oxygenation and carbon dioxide removal during cardiopulmonary bypass in adult patients.
Collection, 40 µm filtration and storage of venous drainage and cardiotomy (suction) blood.
Blood temperature control during perfusion via the integrated heat exchanger.
Vacuum-assisted venous drainage (VAVD) in the sealed reservoir configuration.

Combining the reservoir, cardiotomy, oxygenator and heat exchanger in a single preconnected set simplifies perfusion circuit setup and reduces blood contact with foreign surfaces.

PERFORMANCE DATA

Tested gas and heat transfer performance

237 mL

Low priming volume

Oxygenation chamber priming volume (catalog value).

7 L/dk

Maximum blood flow

Operates across a 1.0 – 7.0 L/min blood flow range.

0,71

Heat exchanger performance factor

At 4 L/min blood flow and 15 L/min water flow.

O₂ transfer (mL/min) vs. blood flow rate

CO₂ transfer (mL/min) vs. blood flow rate

Oxygenation chamber pressure drop ΔP (mmHg)

Heat exchanger performance (in vitro, 15 L/min water flow)

Source: Nipro BRIZIO™ product catalog (CA058(EN) Rev. A) · In vitro tests with bovine blood under ISO 7199 / EN 12022 conditions.

E8 SYNTHETIC COATING

A biocompatible coating that reduces blood–surface contact

NIPRO uses the E8 synthetic coating developed by Toyobo. This polyethylene glycol-based, 100% synthetic (non-biological) functional copolymer coats the oxygenation chamber, polypropylene fibers and heat exchanger, preventing direct contact of blood with plastic surfaces. In liquid phase it forms a non-rigid, homogeneous and continuous membrane.

100% Synthetic Copolymer

A non-biological, polyethylene glycol-based structure with high molecular freedom and aliphatic chain length, offering lasting biocompatibility.

Less Thrombus and Aggregation

In a 3-hour extracorporeal animal perfusion at 7 L/min, E8-coated fibers showed markedly less thrombus formation and platelet aggregation than uncoated fibers.

Lower Complement Activation

In studies, E8-coated BRIZIO™ showed lower activation of the C3 and CH50 inflammatory markers compared with other coatings on the market (p < 0.01, n = 8).

ARCHITECTURE

An integrated circuit designed for the perfusionist

The venous reservoir, separate-chamber cardiotomy system, top-down flow oxygenation chamber and heat exchanger work together for safe, bubble-free, low-volume perfusion.

VENOUS RESERVOIR

Progressive-Filtration Reservoir and Cardiotomy

4000 mL hard-shell reservoir; the 40 µm filter retains unwanted particles and microbubbles.
The venous drainage and vent line route blood directly to the outlet without contact with the reservoir's plastic surfaces.
The separate-chamber cardiotomy system prevents continuous contact of suction blood with venous blood at levels below 1000 mL.
Volume scale in 10 mL steps, with high-contrast yellow marks down to the 200 mL minimum level.

OXYGENATOR

Top-Down Flow Oxygenation Chamber

Blood flows from top to bottom; bubbles and microbubbles are retained at the top of the chamber and kept out of the arterial line.
A quick-positioning clamp lets the chamber rotate 360° on its axis, giving free placement of venous inlet, arterial outlet, recirculation and gas lines.
391 thin-walled, polished stainless steel tubes in the heat exchanger; turbulence-free, near-physiological flow.

HOLDER

Articulated Holder Arms

Bi-articulated arms allow flexible positioning of the oxygenator relative to the patient and the heart-lung machine.
Three holder models: Advanced (SUP-001BRZ), Intermediate (SUP-002BRZ) and Basic (SUP-003BRZ).

TECHNICAL SPECIFICATIONS

Key technical parameters

Reservoir · Blood storage capacity

4000 mL

Reservoir · Minimum operating volume

200 mL

Reservoir · Blood flow range

1.0 – 7.0 L/min

Reservoir · Maximum cardiotomy blood flow

5.0 L/min

Reservoir · Cardiotomy filter element

40 µm

Reservoir · Maximum rated pressure

6.66 kPa (50 mmHg) / −20 kPa (−150 mmHg)

Reservoir · Negative / positive pressure relief valve

−200 ± 5 mmHg / +65 ± 5 mmHg

Reservoir · Venous inlet port

1/2" (12.7 mm)

Reservoir · Reservoir outlet port

3/8" (9.5 mm)

Reservoir · Cardiotomy inlet ports

6 × 1/4" (6.4 mm)

Oxygenator · Hollow fiber membrane

Microporous polypropylene

Oxygenator · Membrane surface area

Approx. 2.2 m²

Oxygenator · Static priming volume

< 270 mL

Oxygenator · Blood flow range

1.0 – 7.0 L/min

Oxygenator · Heat exchanger

Stainless steel, approx. 0.2 m²

Oxygenator · Maximum pressure (blood inlet)

650 mmHg (87 kPa)

Oxygenator · Maximum pressure (water inlet)

1000 mmHg (134 kPa)

Oxygenator · Blood inlet / outlet ports

3/8" (9.5 mm)

Oxygenator · Gas inlet / outlet ports

1/4" (6.4 mm) / 3/8" (9.5 mm)

Oxygenator · Water ports

Hansen quick connect, 1/2" (12.7 mm)

Temperature probe

Yellow Springs type

Coating

NIPRO E8 synthetic coating

Sterilization

Ethylene oxide (EtO)

Oxygenator models

BRZ+12000A · BRZ+12005A · BRZ+12305A · BRZ+12345A

Holder models

SUP-001BRZ (Advanced) · SUP-002BRZ (Intermediate) · SUP-003BRZ (Basic)